HPV detection by in situ hybridisation in sinonasal inverted papilloma and squamous cell carcinoma
Volume: 0 - Issue: 0
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D. Ginström - M. Lundberg - J. Hagström - C. Haglund - E. Auvinen - L.M. Aaltonen - S. Viitasalo
DOI: 10.4193/Rhin26.397
Dear Editor:
Sinonasal inverted papilloma (SNIP) is a rare benign but locally aggressive tumour with an annual incidence of approximately 0.5–1.5/100 000, accounting for 4.7% of all sinonasal tumours. SNIP may recur and can transform into sinonasal squamous cell carcinoma (SNSCC) (1). Human papillomavirus (HPV) has been linked to SNIP recurrence and malignant progression, with a meta-analysis reporting the incidence of HPV in SNIP as 16.9% (2).
This aligns with the results of our previous prospective study (17.8%), showing that the presence of HPV DNA was associated with SNIP recurrence in 90 patients undergoing surgery (3).
Rhinology 0 - 0: 0-0, 0000
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