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Article # 3255
Journal Rhinology 0 - 0
Article Title Association between psychophysically measured olfactory dysfunction and mental health status in long COVID patients
Abstract BACKGROUND: Long COVID frequently presents with persistent olfactory dysfunction (OD), affecting both physical and psychological
well-being. This study aims to evaluate the mental health consequences of OD in long COVID patients. METHODOLOGY: A cross-sectional study involved 86 adult patients. Participants presented OD for at least three months post-COVID-
19 and were evaluated using the extended battery of Sniffin’ Sticks test (SST). Psychological assessments included the Impact
of Event Scale-Revised (IES-R), Beck Hopelessness Scale (BHS), Depression, Anxiety, and Stress Scale-21 (DASS-21), and Quality of
Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q).
RESULTS: Significant differences in mental health factors were observed between patients with and without OD: in comparison
to normosmic patients, hyposmic patients showed higher IES-R Total, Avoidance, and Hyperarousal scores, along with increased
DASS-21 Anxiety scores and BHS total scores.
CONCLUSIONS: OD in long COVID patients were significantly associated with increased post-traumatic stress symptoms, anxiety
symptoms and hopelessness, and with lower quality of life. Limited sample size, inability to determine causation and exploratory
nature of the study may limit the generalizability of results. Comprehensive management addressing both physical and mental
health should be assessed in long COVID patients.
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