Article # 2932
Journal Rhinology 0 - 0
Article Title miRNA-205-5p can be related to T2-polarity in Chronic Rhinosinusitis with Nasal Polyps
Abstract Background: microRNAs (miRNAs) are directly associated with inflammatory response, but their direct role in CRSwNP (chronic rhinosinusitis with nasal polyps) remains evasive. This study aimed to compare the expression of several miRNAs in tissue samples obtained from patients with CRSwNP and controls and to evaluate if miRNAs correlate to a specific inflammatory pattern (T1, T2, T17, and Treg) or intensity of symptoms in CRSwNP.
Methods: nasal polyps (from patients with CRSwNP – n=36) and middle turbinate mucosa (from control patients – n=41) were collected. Microarray determined human mature miRNA expression, and the results obtained were validated by qPCR. miRNAs that were differentially expressed were then correlated to cytokine proteins (by Luminex), tissue eosinophilia, and SNOT-22.
Results: After microarray and qPCR analyses, six microRNAs were up-regulated in CRSwNP samples when compared with controls: miR-205-5p, miR-221-3p, miR-222-3p, miR-378a-3p, miR-449a and miR-449b-5p. All these miRNAs are directly implicated with cell cycle regulation and apoptosis, and to a minor extent, with inflammation. Importantly, miR-205-5p showed a significantly positive correlation with IL-5 concentration and eosinophil count at the tissue and with the worst SNOT-22 score.
Conclusions: miRNA 205-5p was increased in CRSwNP compared to controls, and it was especially expressed in CRSwNP patients with higher T2 inflammation (measured by both IL-5 levels and local eosinophilia) and worst clinical presentation. This miRNA may be an interesting target to be explored in patients with CRSwNP.
Price 25 €
  1. Slot Online
  2. Situs Judi Slot Online Terbaik Indonesia
  3. Situs Judi Slot Online
  4. Daftar Situs Judi Slot Online Terpercaya
  5. Situs Judi Slot Online Terpercaya 2021
  6. Daftar Slot Online
  7. Judi Slot Online Jackpot Terbesar
  8. Judi Slot Online
  9. Agen Slot Online
  10. Game Slot Online
  11. Slot Online Indonesia
  12. Slot Online Terbaik
  13. Judi Slot Online Terpercaya
  14. Slot Online Yang Sering Kasih Jackpot
  15. Slot Online Terbaru
  16. Judi Slot
  17. Slot Gacor