togel online | sbobet | joker123 | slot online | sbobet wap | casino online | poker online | asianbookie | liga88 | luxury138 | HPPOKER | batman88 | slot online | sbobet | Joker123 |

agen slot online | slot online pulsa | slot online | daftar slot online | slot online terbaik | slot online resmi | login sbobet | slot online | sbobet wap | judi bola online | joker123 apk | situs joker123 | casino online | casino online terbaik | login sbobet | agen sbobet | slot online | live slot | togel online | Idn Poker | joker123 | sbobet | situs judi slot | agen slot online | slot online terlengkap | slot online terpercaya | slot online | sbobet | joker123 | idn poker | slot | agen sbobet | sbobet | slot online | idn poker | joker123 | slot online | togel online | sbobet mobile | poker online terpercaya | freebet

Rhinology International Journal
Article # 2918
Journal Rhinology 0 - 0
Article Title Ion concentrations in nasal airway surface liquid: a prediction model for the identification of cystic fibrosis carriers
Abstract Background: Cystic fibrosis (CF) carriers seem to have a higher risk to develop chronic rhino-sinusitis (CRS), although the full underlying mechanisms are unknown. Ion concentrations in nasal airway surface liquid (ASL) may be influenced by the heterozygosity for CF gene mutation, with possible impacts on the development of CRS.
Methods: A cheap and feasible standardized technique was designed to measure the ion levels in nasal ASL. With this purpose we collected, under basal conditions, samples from the nasal cavity of 165 adults: 14 homozygous for CF, 83 carriers and 68 healthy controls. Sodium (Na) and Chlorine (Cl) concentrations were then evaluated among different groups.
Results: Statistical analysis revealed a significant difference of Na and Cl values between controls and carriers and between controls and homozygotes. Receiver operating characteristic (ROC) curves and derived indicators (Youden‘s index and Area Under the Curve, AUC) were used to further evaluate the diagnostic capability of Na and Cl concentrations to differentiate heterozygotes from controls. ROC curves demonstrated that the optimal diagnostic cut-off value of Na is at 124, and the optimal cut-off value of Cl is at 103,2.
Conclusion: ASL sampling can be considered a new diagnostic tool for providing quantitative information on nasal ion composition. According to our findings, Na and Cl concentrations of nasal ASL could represent a useful tool to assess heterozygotes and healthy controls.
Price 25 €

togel online | sbobet | joker123 | slot online | sbobet wap | casino online | poker online | asianbookie | liga88 | luxury138 | HPPOKER | batman88 | slot online | sbobet | Joker123 |

agen slot online | slot online pulsa | slot online | daftar slot online | slot online terbaik | slot online resmi | login sbobet | slot online | sbobet wap | judi bola online | joker123 apk | situs joker123 | casino online | casino online terbaik | login sbobet | agen sbobet | slot online | live slot | togel online | Idn Poker | joker123 | sbobet | situs judi slot | agen slot online | slot online terlengkap | slot online terpercaya | slot online | sbobet | joker123 | idn poker | slot | agen sbobet | sbobet | slot online | idn poker | joker123 | slot online | togel online | sbobet mobile | poker online terpercaya | freebet