Invasive fungal rhinosinusitis in immunocompromised patients
Volume: 42 - Issue: 3
First page: 141 - Last page: 144
W.T. Anselmo-Lima - R.P. Lopes - F.C.P. Valera - R.C. Demarco
DOI: 10.4193/Rhin
Introduction: Invasive fungal rhinosinusitis (IFR) is one of the most important causes of morbidity and mortality in immunocompromised patients, principally those with cellular immunodeficiency, with mortality ranging from 50 to 80%. Prophylaxis and early diagnosis increase the chances of successful treatment.
Study design: Clinical prospective randomized study.
Aim: To present cases of IFR and to compare them with data reported in the literature. Material and methods: Analysis of eleven cases of IFR confirmed by pathologist examination. Results: Aspergillus was found to be the most prevalent pathogen. Symptoms ranged from high fever in most cases to nasal discharge, ulceration of the nasal mucosa, headache and periorbital edema.
Conclusion: The combination of amphotericin B and endoscopic surgery, associated or not with Caldwell-Luc surgery, showed good results. The use of liposomal amphotericin B also presented a satisfactory outcome.
Rhinology 42-3: 141-144, 2004
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