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Volume: 64 - Issue: 1

First page: 137 - Last page: 139

A. Minzoni - P. Orlando - L. Mazzetti - A. Ricchiuti - S. Bresci - G. Maggiore

DOI: 10.4193/Rhin25.243

Olfactory dysfunction is a frequent yet underrecognized manifestation of chronic rhinosinusitis in cystic fibrosis. Despite widespread reports of OD in CF, the impact of CFTR modulator therapy on smell outcomes remains unclear. We conducted a prospective study to evaluate olfactory function changes in CF-related CRS patients, as defined by EPOS2020, following 12 months of elexacaftor/tezacaftor/ivacaftor therapy, exploring clinical and biological correlates. From 120 ETI-treated CF patients at the University Hospital of Careggi, 45 adults diagnosed with CRS completed pre- and post-treatment assessments, including olfactory evaluation via the 16-item Sniffin’ Sticks Identification Test for its feasibility and longitudinal applicability.

Rhinology 64 - 1: 137-139, 2026