Association between olfactory function and quality of life in patients with olfactory disorders: a multicenter study in over 760 participants

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L-q. Zou - T. Hummel - M.S. Otte - T. Bitter - G. Besser - C.A. Mueller - A. Welge-Lüssen - O.C. Bulut - Ö. Göktas - S. Negoias - S-b. Li - A. Haehner

BACKGROUND: This cross-sectional, multi-centric study aimed to investigate the differences in quality of life among patients with olfactory dysfunction (OD) of different origin, and to identify factors associated with olfactory-related quality of life (QOL).
METHODS: Seven hundred sixty-three adults were recruited from 8 Smell & Taste clinics in Germany, Switzerland, and Austria. Olfactory-related QOL was assessed by the Questionnaire of Olfactory Disorders (QOD). Olfactory function was assessed with the “Sniffin’ Sticks” test; self-assessment was performed with visual analog scales.
RESULTS: Patients with post-infectious and post-traumatic OD showed poorer olfactory-related QOL than patients with sinonasal and idiopathic OD. The olfactory-related QOL was positively associated with the Sniffin’ Sticks test score, self-assessed olfactory function, disease duration, and age, with younger olfactory dysfunction patients showing lower QOL. Female patients presented with poorer olfactory-related QOL. In addition, the results showed that self-assessment of olfactory function explained more of the variance in olfactory-related QOL than olfactory function evaluated by the Sniffin’ Sticks test.
CONCLUSIONS: In addition to the psychophysical testing results, several factors such as disease cause, disease duration, sex, or self- assessed olfactory dysfunction should be taken into account when assessing the individual severity of the smell loss.

L-q. Zou - T. Hummel - M.S. Otte - T. Bitter - G. Besser - C.A. Mueller - A. Welge-Lüssen - O.C. Bulut - Ö. Göktas - S. Negoias - S-b. Li - A. Haehner - Association between olfactory function and quality of life in patients with olfactory disorders: a multicenter study in over 760 participants

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