To see the issue content and the abstract you do not have to login
Please login to download the full articles

Emailadres
Password
Lost password?      Click here!

If you do not have a subscription to Rhinology please consider to take one.
Click here to become a member of the European Rhinologic Society and a subscriber to the journal `RHINOLOGY`, beginning 2020. Subscription including membership fee: Euro 139.-

Free Download


Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial

Volume: 0 - Issue: 0

Firstpage: 0 - Lastpage: 0

I.S. de Oliveira - A.F. Guimaraes - G.F. Arantes Pêgas - C.J. Machado - G.D. Cassali - F. Barbosa Nunes - H.M. Gonçalves Becker - R.E. Santos Guimarães

BACKGROUND: Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use of a placebo in patients presenting with CRSwNP concomitant with asthma and aspirin intolerance after 3 months of treatment and at a 1-year follow-up.
METHODOLOGY: We performed a randomised, double-blind, placebo-controlled trial. Patients received 500 mg azithromycin orally three times/week for 12 weeks. Improvement was evaluated by staging, the Sino-Nasal Outcome Test (SNOT-22), and nasal polyp biopsy. Data collected at pretreatment and 3 months posttreatment were compared. Quality of life was evaluated at the 1-year follow-up.
RESULTS: Twenty-seven and 21 patients were treated with azithromycin and a placebo, respectively. The medication was well tolerated overall. Twenty patients (74%) in the azithromycin group and three patients (14%) in the placebo group were not refer- red for surgery at the end of the 3-month treatment. Regarding subjective improvement, there was a median decrease only in the azithromycin group, and the between-group difference was significant. SNOT-22 improvement was maintained in the azithromy- cin group at the 1-year follow-up.
CONCLUSIONS: Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance.

I.S. de Oliveira - A.F. Guimaraes - G.F. Arantes Pêgas - C.J. Machado - G.D. Cassali - F. Barbosa Nunes - H.M. Gonçalves Becker - R.E. Santos Guimarães - Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial
Rhinology 0-0: 0-0, 0000