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Extended approach or usage of nasoseptal flap is a risk factor for olfactory dysfunction after endoscopic anterior skullbase surgery: results from 928 patients in a single tertiary center

Volume: - Issue:

Firstpage: 0 - Lastpage: 0

M. Y. Seo - D-H. Nam - D-S. Kong - S.H. Lee - Y. Noh - Y.G. Jung - H.Y. Kim - S-K. Chung - K.E. Lee - S.D. Hong

BACKGROUND: The aim of this study was to compare olfactory function change in patients who underwent endoscopic skull-base surgery.
METHODOLOGY: A total of 928 patients were included in this retrospective study. Olfactory function was measured using the non- validated Likert scale (0–100), the Cross-Cultural Smell Identification Test (CC-SIT) and the butanol threshold test (BTT). Patients were divided into two groups: an endoscopic trans-sellar approach group (ETA, n = 768) and an extended endoscopic endonasal approach group (EEEA, n = 160). The ETA group was sub-divided into Nasoseptal flap (NSF) and no NSF groups.
RESULTS: Non-validated olfactory function significantly worsened in the EEEA and ETA-NSF groups compared with that in the ETA- no NSF group for at least 6 months post-operatively. Validated olfactory impairment (BTT and CC-SIT) was also significantly worse in the EEEA and NSF groups compared with that in the ETA-no NSF group 3 months post-operatively. Additionally, the degrees of non-validated and validated olfactory deterioration were not significantly different between the EEEA and ETA-NSF groups. We also found that CC-SIT score changes were significantly impaired in tuberculum sellae meningioma patients than in craniopharyn- gioma patients.
CONCLUSIONS: We conclude that NSF was the key factor that led to olfactory impairment after endoscopic skull-base surgery.

M. Y. Seo - D-H. Nam - D-S. Kong - S.H. Lee - Y. Noh - Y.G. Jung - H.Y. Kim - S-K. Chung - K.E. Lee - S.D. Hong - Extended approach or usage of nasoseptal flap is a risk factor for olfactory dysfunction after endoscopic anterior skullbase surgery: results from 928 patients in a single tertiary center
Rhinology -: 0-0, 0000