togel online | sbobet | joker123 | slot online | sbobet wap | casino online | poker online | asianbookie | liga88 | luxury138 | HPPOKER | batman88 | slot online | sbobet | Joker123 |

agen slot online | slot online pulsa | slot online | daftar slot online | slot online terbaik | slot online resmi | login sbobet | slot online | sbobet wap | judi bola online | joker123 apk | situs joker123 | casino online | casino online terbaik | login sbobet | agen sbobet | slot online | live slot | togel online | Idn Poker | joker123 | sbobet | situs judi slot | agen slot online | slot online terlengkap | slot online terpercaya | slot online | sbobet | joker123 | idn poker | slot | agen sbobet | sbobet | slot online | idn poker | joker123 | slot online | togel online | sbobet mobile | poker online terpercaya | freebet

Rhinology International Journal

Free Download

Multivariate analysis of inflammatory endotypes in recurrent nasal polyposis in a Chinese population

Volume: 56 - Issue: 3

First page: 216 - Last page: 226

B. Wei - F. Liu - J. Zhang - Y. Liu - J. Du - S. Liu - N. Zhang - C. Bachert - J. Meng

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare.
METHODS: 78 CRSwNP patients undergoing functional endoscopic sinus surgery were followed-up for 8 years and classified into recurrent and non-recurrent groups. A cluster analysis of the CRSwNP based on inflammatory endotypes was performed, and the endotypes were secondarily matched with clinical phenotypes.
RESULTS: The recurrence rate of CRSwNP in Southwest China was 21.8% over 8 years post-surgery. The CRSwNP was classified into 4 clusters: cluster 1 (higher expression of IL-5, IgE, and ECP and high positivity rate for SE-IgE); cluster 2 (higher concentrations of IL-6, IL-8 and MPO); cluster 3 (higher concentrations of TNF-alpha; and IFN-gamma); and cluster 4 (higher expression of IL-17). Cluster 1 (type-2 inflammation) exhibited the highest recurrence rate, co-morbid asthma and atopy. Notably, the ECP/MPO ratio increased significantly in patients with non-type-2 recurrent CRSwNP 8 years after the first surgery.
CONCLUSION: Different inflammatory endotypes of CRSwNP exhibited clearly different prognoses. The type-2 subgroup had high recurrence and co-morbid asthma rates comparable to the rates reported in Western countries.

Rhinology 56-3: 216-226, 2018

To see the issue content and the abstract you do not have to login

Please login to download the full articles

If you do not have a subscription to Rhinology please consider taking one.

Click here to become a member of the European Rhinologic Society and a subscriber to the journal `RHINOLOGY`, from 2022. Subscription including membership fee: Euro 135.-

togel online | sbobet | joker123 | slot online | sbobet wap | casino online | poker online | asianbookie | liga88 | luxury138 | HPPOKER | batman88 | slot online | sbobet | Joker123 |

agen slot online | slot online pulsa | slot online | daftar slot online | slot online terbaik | slot online resmi | login sbobet | slot online | sbobet wap | judi bola online | joker123 apk | situs joker123 | casino online | casino online terbaik | login sbobet | agen sbobet | slot online | live slot | togel online | Idn Poker | joker123 | sbobet | situs judi slot | agen slot online | slot online terlengkap | slot online terpercaya | slot online | sbobet | joker123 | idn poker | slot | agen sbobet | sbobet | slot online | idn poker | joker123 | slot online | togel online | sbobet mobile | poker online terpercaya | freebet

togel online | sbobet | joker123 | slot online | sbobet wap | casino online | poker online | asianbookie | liga88 | luxury138 | HPPOKER | batman88 | slot online | sbobet | Joker123 |

agen slot online | slot online pulsa | slot online | daftar slot online | slot online terbaik | slot online resmi | login sbobet | slot online | sbobet wap | judi bola online | joker123 apk | situs joker123 | casino online | casino online terbaik | login sbobet | agen sbobet | slot online | live slot | togel online | Idn Poker | joker123 | sbobet | situs judi slot | agen slot online | slot online terlengkap | slot online terpercaya | slot online | sbobet | joker123 | idn poker | slot | agen sbobet | sbobet | slot online | idn poker | joker123 | slot online | togel online | sbobet mobile | poker online terpercaya | freebet