To see the issue content and the abstract you do not have to login

Please login to download the full articles

If you do not have a subscription to Rhinology please consider to take one.

Click here to become a member of the European Rhinologic Society and a subscriber to the journal `RHINOLOGY`, beginning 2020. Subscription including membership fee: Euro 139.-

Free Download

Parkinson disease in eldery patients: lessons from odour detection thresholds on olfacto-trigeminal interaction

Volume: 56 - Issue: 2

First page: 127 - Last page: 132

C. Foguem - M. Lemdani - C. Huart

BACKGROUND: Human nasal chemosensation is mediated by two separate, though interacting sensory pathways: the trigeminal and olfactory systems. Trigeminal sensitivity and olfacto-trigeminal interactions have not yet been well studied in idiopathic Parkinsons disease (IPD).
OBJECTIVES: The aim of this study was to assess odour detection thresholds in elderly IPD patients, and compare them to the odour detection thresholds of healthy controls. Finally, we investigated potential interactions between trigeminal and olfactory sensitivity.
METHODS: 89 IPD patients aged over 65 and 89 matched healthy participants were enrolled in the study. Odour detection thresholds to 3 stimuli differentially activating olfactory and trigeminal afferents (Phenyl-ethyl alcohol, n-Butanol and Pyridine) were assessed, using an ascending staircase, binary forced-choice procedure.
RESULTS AND CONCLUSION: Detection threshold scores were able to discriminate between elderly IPD and controls. Pyridine was less effective than the two other odorants, suggesting that trigeminal pathway is less impaired than the olfactory system. We found that the detection thresholds were significantly different between IPD patients with good autonomy, and patients with impaired autonomy.

C. Foguem - M. Lemdani - C. Huart - Parkinson disease in eldery patients: lessons from odour detection thresholds on olfacto-trigeminal interaction

Rhinology 56-2: 127-132, 2018