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Volume: 30 - Issue: 2

First page: 103 - Last page: 112

Y Qvarnberg - O Kantola - J. Salo - M. Toivanen - H. Valtonen - E. Vuori

DOI: 10.4193/Rhin10.4193/Rhin92.204

The clinical efficacy and adverse effects of budesonide administered as a nasal aerosol
in addition to sinus washings and erythromycin therapy was assessed by comparison
with placebo in a randomized, double-blind study of 40 patients with chronic or
recurrent maxilla,y sinusitis. Most o f the patients had been referred for operative
treatment. Corticosteroid therapy, 400 μg daily, or placebo was continued for
3 months. Budesonide and antral irrigations reduced nasal symptoms more effectively
than placebo, and there was a significantly greater reduction in facial pain and
sensitivity in the budesonide group than in the placebo group. During the treatment
period, mucosa! thickening as evaluated by radiology decreased more clearly in the
budesonide group than in the placebo group, but the difference did not reach
statistical significance. The most frequently isolated bacteria were Staphylococcus
aureus, Staphylococcus epidermidis and Haemophilus influenzae. Only 2 of 20
Haemophilus strains were ./3-factamase producers. The cellular picture was
dominated by neutrophils in all secretions. There was no significant difference in
clinical outcome between the two groups. Topical steroid therapy did not cause any
adverse effects.

Rhinology 30-2: 103-112, 1992