International Rhinologic Society Rhinology 0300-0729 2026 10 13 New CRS control tests: development and validation by EUFOREA EN D.M. ContiEscuela de Doctorado UAM, Centro de Estudios de Posgrado, Universidad Autónoma de Madrid. Calle Francisco Tomás y Valiente, nº 2, Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain Allergy and Clinical Immunology Research Unit, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, W.J. Fokkens Amsterdam UMC, University of Amsterdam, Department of Otorhinolarynogology, Amsterdam, the Netherlands G.K. Scadding Department of Allergy and Rhinology, Royal National ENT Hospital, London, United Kingdom V. Backer Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark S. Lau Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany X. Bertels Scientific Expert Team Members, The European Forum for Research and Education in Allergy and Airway Diseases, Brussels, Belgium K. Aanaes Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark M.P. Aguilera Quezada Rhinology and Skull Base Unit, Department of Otolaryngology, Hospital Clínic de Barcelona, Barcelona, Spain A. Alani Dept. of Otolaryngology- Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA I. Alobid Rhinology and Skull Base Unit, Department of Otolaryngology, Hospital Clínic de Barcelona, Medical School, Barcelona University, Barcelona, Spain E. Anisman Dept. of Otolaryngology- Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA Y. Chan Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada J. Constantinidis 1st Academic Otorhinolaryngology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece M. CorbòUnit of Otorhinolaryngology and Head-Neck Surgery, “A. Gemelli” Hospital Foundation IRCCS, Rome, Italy Department of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, Rome, Italy M. Cornet Alrijne Ziekenhuis, Leiderdorp, the Netherlands E.J. Correa Departamento de Otorrinolaringología, Quironsalud Marbella y Hospital Campo de Gibraltar, 29603, Marbella, España L.M. D´Auria Department of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, Rome, Italy E. de CorsoUnit of Otorhinolaryngology and Head-Neck Surgery, “A. Gemelli” Hospital Foundation IRCCS, Rome, Italy Department of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, Rome, Italy A. Del Cuvillo Rhinology and Asthma Unit, Otolaryngology Department, Jerez University Hospital, Cadiz, Spain M. Doulaptsi Department of Otorhinolaryngology, University of Crete, School of Medicine, Heraklion, Greece A. García-Lliberós Rhinology and Skull Base Surgery, ENT Department, Valencia University General Hospital, Valencia, Spain F. García RíoServicio de Neumología, Hospital Universiario La Paz-IdiPAZ, Madrid, Spain CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain Departamento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain P. Gevaert Department of Otorhinolaryngology, Laboratory of Upper Airways Research, University of Ghent, Ghent, Belgium J. Han Department of Otolaryngology and Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA, USA J. LeeDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA, USA Department of Surgery, Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA, USA K. Limage Dept. of Otolaryngology- Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA G. Liva Department of Otorhinolaryngology, University of Crete, School of Medicine, Heraklion, Greece D.R. LoboOtolaryngology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain IDIVAL: Valdecilla Biomedical Research Institute, Santander, Spain A. Manole University of Oradea, Faculty of Medicine and Pharmacy Oradea, Oradea, Roemenië F. Manole University of Oradea, Faculty of Medicine and Pharmacy Oradea, Oradea, Roemenië F. Mariño-Sanchez Rhinology and Skull Base Unit, Otolaryngology Department, Ramón y Cajal University Hospital, Madrid, Spain J. Maza-SolanoRhinology and Skull Base Unit, Department of Otolaryngology, University Hospital Virgen del Rocío, Seville, Spain Department of Surgery, University of Seville, Seville, Spain QUIRONSALUD Sagrado Corazón, Seville, Spain C. MontuoriUnit of Otorhinolaryngology and Head-Neck Surgery, “A. Gemelli” Hospital Foundation IRCCS, Rome, Italy Department of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, Rome, Italy R. Moreno-Luna Rhinology and Skull Base Unit, Otolaryngology Department, University Hospital Virgen Macarena, Seville, Spain X.I. Mota Rojas Departamento de Otorrinolaringología, Hospital El Bierzo, Ponferrada, Spain G.B. Patel Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA A. Peters Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA E. ProkopakisDepartment of Otorhinolaryngology, University of Crete, School of Medicine, Heraklion, Greece Laboratory of Translational Otorhinolaryngology Research, University of Crete School of Medicine, Heraklion, Greece S. QuirceCIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain Servicio de Alergia, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain D. Ramdhani Westville Independent Practioners association at Life Westville Hospital, South Africa S. Reitsma Amsterdam UMC, University of Amsterdam, Department of Otorhinolarynogology, Amsterdam, the Netherlands A. Sánchez Barrueco Department of Medicine, Villalba General University Hospital, Collado Villalba, Spain A. Santamaría- Gadea Rhinology and Skull Base Unit, Otolaryngology Department, Ramón y Cajal University Hospital, Madrid, Spain S. Sánchez Gómez Spanish Otolaryngology, Head and Neck Society, Head of Otolaryngology Department, Virgen Macarena University Hospital, Seville, Spain T. Sarafidou 1st Academic Otolaryngology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece S. Snoeks Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals, Leuven, Belgium W. Thorley Division of Otolaryngology-Head and Neck Surgery, Brigham and Women’s Hospital, Boston, MA, USA E. Toskala Dept. of Otolaryngology- Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA M. Tucciarone Otolaryngology Department, Puerta del Mar University Hospital, Cadiz, Spain G. VerstappenDepartment of Otorhinolaryngology-Head and Neck Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Health Campus, Brussels, Belgium Allergy and Clinical Immunology Research Unit, KU Leuven Department of Microbiology and Immunology, Leuven, Belgium Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium J.M. Villacampa Aubá Otolaryngology Department, Fundación Jimenez Díaz University Hospital, Madrid, Spain I.M. Villarreal Patiño Rhinology Unit, Department of Otorhinolaryngology, Fuenlabrada University Hospital, Madrid, Spain M. Wagenmann Department of Otorhinolaryngology, Universitätsklinikum Düsseldorf, Dusseldorf, Germany L.M. Wang Northwestern University Feinberg School of Medicine, Chicago, IL, USA C. Almansa Sanofi, Cambridge, MA, USA A.B. Gandhi Sanofi, Cambridge, MA, USA S.D. Nash Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA A. Radwan Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA Z. Wang Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA A. Belmans Interuniversity Centre for Biostatistics and Statistical Bioinformatics, KU Leuven, Leuven, Belgium P.W. HellingsAllergy and Clinical Immunology Research Unit, KU Leuven Department of Microbiology and Immunology, Leuven, Belgium Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium Laboratory of Upper Airways Research, Department of Otorhinolaryngology, University of Ghent, Ghent, Belgium Journal Article 3637 10.4193/Rhin26.139 BACKGROUND: Measuring control in Chronic Rhinosinusitis (CRS) is important in clinical evaluation. We developed and validated 2 new tests for the evaluation of control in CRS, the 6-item CRS Control Test (CCT) and the 14-item CRS Patient Control Test (CPCT) and investigated their correlations with existing tools. METHODS: An international survey was conducted in 1,102 CRS patients in 19 centres in 7 countries using a questionnaire including the newly developed CCT and CPCT, VAS scores for CRS severity and control, the EPOS control test (EPOSCT), the Sino-Nasal Outcome Test 22 (SNOT-22) and the Patient Global Assessment Tool (PGAT). We evaluated convergent and discriminative validity, internal consistency and cross-cultural validity. Furthermore, we performed an Item Response Theory (IRT) analysis and determined cut-off points for CCT and CPCT. Sub-analyses were performed for CRS patients with and without nasal polyps. RESULTS: Both CCT (0-24) and CPCT (0-56) demonstrated a high correlation with SNOT-22 and the PGAT. Moderate correlations were observed for all other comparisons. Both tests showed good internal consistency, discriminative validity and cross-cultural validity. We propose for CCT ≤15 to indicate uncontrolled, 16-19 partially controlled, and ≥20 well controlled disease. For the CPCT we propose ≥22 for uncontrolled, 13-21 for partially controlled and ≤12 for well controlled disease. CONCLUSION: The brief CCT and the longer CPCT are new CRS control tests that show moderate to high correlations with existing tools. Both instruments demonstrated good psychometric properties and therefore can be recommended for use in clinical practice and research.