International Rhinologic Society Rhinology 0300-0729 2026 08 11 Effectiveness of mepolizumab in eosinophilic asthma and chronic rhinosinusitis with nasal polyps EN E. ChinerPulmonology Department, San Juan de Alicante University Hospital, Alicante, Spain Department of Clinical Medicine, Miguel Hernández University, Elche, Alicante, Spain I. Boira Pulmonology Department, San Juan de Alicante University Hospital, Alicante, Spain J.L. Lafuente Otorhinolaryngology Department, San Juan de Alicante University Hospital, Alicante, Spain M. Antón Allergy Department, San Juan de Alicante University Hospital, Alicante, Spain M.A. Bernabeu Pharmacy Department, San Juan de Alicante University Hospital, Alicante, Spain P. Fernández Pulmonology Department, San Juan de Alicante University Hospital, Alicante, Spain V. Esteban Pulmonology Department, San Juan de Alicante University Hospital, Alicante, Spain M. Llombart Pulmonology Department, San Juan de Alicante University Hospital, Alicante, Spain Letter 3492 10.4193/Rhin26.207 Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease affecting 2–4% of the population which has a significant impact on quality of life. Approximately 40% to 60% of people with CRSwNP also have eosinophilic asthma, reflecting the unified airway concept characterised by type 2 inflammation driven by interleukin (IL)-4, IL-5 and IL-13.