International Rhinologic Society Rhinology 0300-0729 2026 06 05 Impact of real-world confounders on the accuracy of an AI model to support read out of skin prick automated test results EN K. Roux Department of Otorhinolaryngology, Head and Neck Surgery, UZ Leuven, Leuven, Belgium S.F. SeysHippo Dx, Aarschot, Belgium Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria V. Hox Service d'Otorhinolaryngologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium A.M. Chaker Department of Otorhinolaryngology and Center of Allergy and Environment (ZAUM), TUM School of Medicine and Health, TUM University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany P.W. HellingsDepartment of Otorhinolaryngology, Head and Neck Surgery, UZ Leuven, Leuven, Belgium Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology G. de Greve Department of Otorhinolaryngology-Head and Neck Surgery, ZAS Sint-Augustinus, Antwerp, Belgium W. Lemmens Department of Otorhinolaryngology-Head and Neck Surgery, ZOL, Genk, Belgium A.L. Poirrier ENT Department, CHU Liège, Liège, Belgium R. DaemsAffiliation1 Hippo Dx, Aarschot, Belgium. Affiliation2 IDLab, Ghent University-imec, Ghent, Belgium D. Loeckx Hippo Dx, Aarschot, Belgium S. GorrisHippo Dx, Aarschot, Belgium Department of Otorhinolaryngology, AZ Herentals, Herentals, Belgium L. van GervenDepartment of Otorhinolaryngology, Headlogy, and Neck Surgery, UZ Leuven, Leuven, Belgium Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology Letter 3474 10.4193/Rhin25.634 Skin prick testing (SPT) is the gold standard for diagnosing allergic sensitization in individuals with a suspected airborne allergy (1). Skin tests are used as first option in 90% of individuals suffering from respiratory allergies and almost two-third of all types of allergies (2).