International Rhinologic Society Rhinology 0300-0729 2026 04 02 Regional disparities in cost-effectiveness of biologics for CRSwNP should not modify the strategy EN M. FieuxHospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’ORL, d’otoneurochirurgie et de chirurgie cervico-faciale, Pierre Bénite, France Université de Lyon, Université Lyon 1, Lyon, France UMR 5305, Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Institut de Biologie et Chimie des Protéines, CNRS/Université Claude Bernard Lyon 1, Lyon, France F. CarsuzaaService ORL, Chirurgie Cervico-Maxillo-Faciale et Audiophonologie, Centre Hospitalier Universitaire de Poitiers, Poitiers, France Laboratoire Inflammation Tissus Epithéliaux et Cytokines (LITEC), UR15560, Université de Poitiers, Poitiers, France M. Chang Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States P.H. Hwang Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States Z.M. Patel Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States S. TringaliHospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’ORL, d’otoneurochirurgie et de chirurgie cervico-faciale, Pierre Bénite, France Université de Lyon, Université Lyon 1, Lyon, France UMR 5305, Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Institut de Biologie et Chimie des Protéines, CNRS/Université Claude Bernard Lyon 1, Lyon, France V. FavierDépartement d’ORL, chirurgie cervico faciale et maxillo-faciale, Hôpital Gui de Chauliac, CHU de Montpellier, Montpellier, France Research-team ICAR, Laboratory of Computer Science, Robotics and Microelectronics of Montpellier (LIRMM), Univ. Montpellier, French National Centre for Scientific Research (CNRS), Montpellier, France J. MargierHospices Civils de Lyon, Pôle de Santé Publique, Service d’Évaluation Économique en Santé, Research on Healthcare Performance (RESHAPE), INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France Journal Article 3395 10.4193/Rhin25.548 Chronic rhinosinusitis with nasal polyps (CRSwNP) represents a significant burden on the healthcare system. Xian et al. discussed several aspects of our economic model, based on French pricing, that may impact the cost-effectiveness of biologics . Briefly, they outlined the regional disparities in the cost of biologics, the potential better outcomes of biologics in real-world evidence, and the recurrence rate after endoscopic sinus surgery (ESS). We think that these aspects may be further discussed.