International Rhinologic Society Rhinology 0300-0729 2026 01 10 Higher rate of local recurrence in sinonasal squamous cell carcinoma arising from inverted papilloma compared to de novo tumours EN M-H. DongDivision of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Department of Education and Research, Taipei Veterans General Hospital, Taipei, Taiwan Y-W. Chen Department of Otorhinolaryngology, Chi-Mei Medical Centre Y-W. HuangDivision of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Department of Otolaryngology, National Yang Ming Chiao Tung University, Taipei, Taiwan L-T. HungDivision of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Department of Otolaryngology, National Yang Ming Chiao Tung University, Taipei, Taiwan C-F. YehDivision of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Department of Otolaryngology, National Yang Ming Chiao Tung University, Taipei, Taiwan M-Y. LanDivision of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Department of Otolaryngology, National Yang Ming Chiao Tung University, Taipei, Taiwan Y-T. ChaoDivision of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan Department of Otolaryngology, National Yang Ming Chiao Tung University, Taipei, Taiwan Journal Article 3389 10.4193/Rhin25.283 Squamous cell carcinoma (SCC) is the most common histological subtype of sinonasal malignancies. Due to non-specific symptoms, sinonasal SCC (SNSCC) is often diagnosed late, posing challenges for management. SNSCC can arise de novo (DN-SCC) or from the malignant transformation of inverted papilloma (IP-SCC). Prior studies have reported inconsistent outcomes comparing these two subtypes. This study compares recurrence patterns and survival outcomes of DN-SCC and IP-SCC, identifies predictors of recurrence and survival, and aims to inform clinical decision-making and patient counselling.