International Rhinologic Society Rhinology 0300-0729 2026 03 23 Olfactory dysfunction in adult cystic fibrosis patients EN A. Minzoni Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy P. Orlando Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy L. Mazzetti Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy A. Ricchiuti Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy S. Bresci Cystic Fibrosis Unit, Careggi University Hospital, Florence, Italy G. Maggiore Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy Journal Article 3386 10.4193/Rhin25.243 Olfactory dysfunction is a frequent yet underrecognized manifestation of chronic rhinosinusitis in cystic fibrosis. Despite widespread reports of OD in CF, the impact of CFTR modulator therapy on smell outcomes remains unclear. We conducted a prospective study to evaluate olfactory function changes in CF-related CRS patients, as defined by EPOS2020, following 12 months of elexacaftor/tezacaftor/ivacaftor therapy, exploring clinical and biological correlates. From 120 ETI-treated CF patients at the University Hospital of Careggi, 45 adults diagnosed with CRS completed pre- and post-treatment assessments, including olfactory evaluation via the 16-item Sniffin’ Sticks Identification Test for its feasibility and longitudinal applicability.