International Rhinologic Society Rhinology 0300-0729 2026 10 11 Health related quality of life in sinonasal disease EN V.J. Lund Royal National Throat Nose and Ear Hospital, London, United Kingdom. Journal Article 1 10.4193/Rhin Objective measurements of sinonasal disease have proved difficult to standardise and correlate poorly with the severity of symptoms. Quality of life, which has been defined as the gap between expectation and experience allows the impact of disease to be quantified thus enabling comparison of different diseases and enabling examination of therapeutic response. A range of generic and disease specific questionnaires have been developed of varying complexity. These have been applied to a range of sinonasal conditions including allergy, infection and neoplasia. With increasing refinement they may become the main primary outcome measures in both clinical trials and practice.