Correlation between the cytology of the nasal middle meatus and BAL in chronic rhinosinusitis
Volume: 43 - Issue: 1
First page: 11 - Last page: 17
A. Ragab - P. Clement - W. Vincken
DOI: 10.4193/Rhin
The relation between chronic rhinosinusitis (CRS) and the associated lower airways involvement
is not clear yet. In this context, the aim of this prospective study was to evaluate the
correlation between middle meatal lavage (MML) and bronchoalveolar lavage (BAL) cytology
in adult CRS patients. Based on clinical history and pulmonary function changes, CRS
patients were divided into three subgroups: asthma, small airway disease (SAD) and normal
lower airway (NLA) subgroups.
Preoperatively, 50 MMLs and 25 BALs were performed in 25 CRS patients scheduled for
FESS. At 1000X power microscopic magnifications, 48 MML and 24 BAL cytospin slides
were examined for total and differential cell counts (DCC). This study showed that
eosinophils were the dominant inflammatory cells in MMLs of the asthma subgroup and
were significantly correlated to FEVI (p=0.042) and Tiffineau index (p=0.037). On the other
hand, neutrophils were the dominant inflammatory cells in MMLs of the SAD subgroup and
significantly correlated to FEF75% and Tiffinau index (p=0.013 and p=0.012 respectively).
There was no significant correlation between MML and BAL cell differential counts in CRS
patients (p>0.05). The data showed that the lower airways involvement in CRS patients
could be related to the dominant type of inflammatory cells in the upper airways.
Rhinology 43-1: 11-17, 2005
