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Eicosanoid imbalance correlates in vitro with the pattern of clinical symptoms of Samter ́s triad

Volume: 51 - Issue: 1

Firstpage: 61 - Lastpage: 69

U. Förster - S. Strathmann - D. Schäfer - A.J. Szczepek - H. Olze

BACKGROUND: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with chronic rhinosinusitis (CRS), nasal polyps (CRSwNP) and asthma, together known as Samters triad. The disease is characterised by eicosanoid imbalan- ce. In our study, we determined clinical and laboratory parameters in respect of three groups of patients: 1) CRSwNP, 2) CRSwNP and asthma (CRSwNP-A), and 3) CRSwNP with asthma and NSAID-triggered hypersensitivity (CRSwNP-AA). Our main goal was to improve the characterisation of the stages of development in Samter ́s triad, pointing to the homogeneous or heterogeneous course of disease.
METHODOLOGY: Forty-three patients (10 CRSwNP, 14 CRSwNP-A, 19 CRSwNP-AA) and 10 control subjects were included in the study. Nasal assessment using the CRS visual analogue score, endoscopy- and computer tomography scores, allergy tests, analysis of sinus surgeries, asthma severity and in vitro functional eicosanoid tests (FET) with peripheral blood leucocytes were performed.
RESULTS: The scores reflecting CRS symptoms such as nasal congestion, nasal discharge and smell impairment differed between the patients groups reflecting the severity of disease (CRSwNP-AA > CRSwNP-A > CRSwNP). Eicosanoid imbalance correlated with nasal congestion, nasal discharge and loss of smell.
CONCLUSION: The data presented support the hypothesis of the continuous development of NSAID-triggered hypersensitivity, culminating in Samter’s triad.

U. Förster - S. Strathmann - D. Schäfer - A.J. Szczepek - H. Olze - Eicosanoid imbalance correlates in vitro with the pattern of clinical symptoms of Samter ́s triad
Rhinology 51-1: 61-69, 2013

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